Department of Molecular Biotechnology and Health Sciences

Research products

Selected research products

Wyart, Elisabeth, Reano, Simone, Hsu, Myriam Y, Longo, Dario Livio, Li, Mingchuan, Hirsch, Emilio, Filigheddu, Nicoletta, Ghigo, Alessandra, Riganti, Chiara, Porporato, Paolo Ettore (2018)
Metabolic Alterations in a Slow-Paced Model of Pancreatic Cancer-Induced Wasting.
https://iris.unito.it/handle/2318/1670017

Porporato, Paolo Ettore, Filigheddu, Nicoletta, Pedro, José Manuel Bravo-San, Kroemer, Guido, Galluzzi, Lorenzo (2018)
Mitochondrial metabolism and cancer.
https://iris.unito.it/handle/2318/1661659

De Santis, Maria Chiara, Porporato, Paolo Ettore, Martini, Miriam*, Morandi, Andrea (2018)
Signaling pathways regulating redox balance in cancer metabolism.
https://iris.unito.it/handle/2318/1691013

Li, Mingchuan, Sala, Valentina, De Santis, Maria Chiara, Cimino, James, Cappello, Paola, Pianca, Nicola, Di Bona, Anna, Margaria, Jean Piero, Martini, Miriam, Lazzarini, Edoardo, Pirozzi, Flora, Rossi, Luca, Franco, Irene, Bornbaum, Julia, Heger, Jacqueline, Rohrbach, Susanne, Perino, Alessia, Tocchetti, Carlo G, Lima, Braulio H F, Teixeira, Mauro M, Porporato, Paolo E, Schulz, Rainer, Angelini, Annalisa, Sandri, Marco, Ameri, Pietro, Sciarretta, Sebastiano, Lima-Júnior, Roberto César P, Mongillo, Marco, Zaglia, Tania, Morello, Fulvio, Novelli, Francesco, Hirsch, Emilio, Ghigo, Alessandra (2018)
Phosphoinositide 3-Kinase Gamma Inhibition Protects from Anthracycline Cardiotoxicity and Reduces Tumor Growth.
https://iris.unito.it/handle/2318/1662394

Bindels, Laure B , Porporato, Paolo E , Ducastel, Sarah, Sboarina, Martina, Neyrinck, Audrey M , Dewulf, Evelyne M , Feron, Olivier, Lestavel, Sophie, Cani, Patrice D , Staels, Bart, Sonveaux, Pierre, Delzenne, Nathalie M (2017)
Ffar2 expression regulates leukaemic cell growth in vivo.
https://iris.unito.it/handle/2318/1661703

Danhier, Pierre, Bański, Piotr, Payen, Valéry L, Grasso, Debora, Ippolito, Luigi, Sonveaux, Pierre, Porporato, Paolo E (2017)
Cancer metabolism in space and time: Beyond the Warburg effect.
https://iris.unito.it/handle/2318/1638236

Baldini N, De Milito A, Feron O, Gillies RJ, Michiels C, Otto AM, Pastoreková S, Pedersen SF, Porporato PE, Sonveaux P, Supuran CT, Avnet S (2017)
Annual meeting of the International Society of Cancer Metabolism (ISCaM): Metabolic networks in cancer.
https://iris.unito.it/handle/2318/1678772

Payen, Valéry L , Hsu, Myriam Y , Rädecke, Kristin S , Wyart, Elisabeth, Vazeille, Thibaut, Bouzin, Caroline, Porporato, Paolo E , Sonveaux, Pierre* (2017)
Monocarboxylate transporter MCT1 promotes tumor metastasis independently of its activity as a lactate transporter.
https://iris.unito.it/handle/2318/1661661

Contino S, Porporato PE, Bird M, Marinangeli C, Opsomer R, Sonveaux P, Bontemps F, Dewachter I, Octave JN, Bertrand L, Stanga S, Kienlen-Campard P (2017)
Presenilin 2-dependent maintenance of mitochondrial oxidative capacity and morphology.
https://iris.unito.it/handle/2318/1678774

Pérez-Escuredo, Jhudit, Dadhich, Rajesh K, Dhup, Suveera, Cacace, Andrea, Van Hée, Vincent F, De Saedeleer, Christophe J, Sboarina, Martina, Rodriguez, Fabien, Fontenille, Marie-Joséphine, Brisson, Lucie, Porporato, Paolo E, Sonveaux, Pierre (2016)
Lactate promotes glutamine uptake and metabolism in oxidative cancer cells.
https://iris.unito.it/handle/2318/1657310

Porporato, P E (2016)
Understanding cachexia as a cancer metabolism syndrome.
https://iris.unito.it/handle/2318/1657312

Avnet, S, Baldini, N, Di Pompo, G, Sonveaux, P, Zini, N, Porporato, Pe, Sboarina, M, Lemma, S (2016)
Energy metabolism in osteoclast formation and activity.
https://iris.unito.it/handle/2318/1657307

Porporato, Paolo E , Payen, Valéry L , Pérez-Escuredo, Jhudit, De Saedeleer, Christophe J , Danhier, Pierre, Copetti, Tamara, Dhup, Suveera, Tardy, Morgane, Vazeille, Thibaut, Bouzin, Caroline, Feron, Olivier, Michiels, Carine, Gallez, Bernard, Sonveaux, Pierre (2014)
A mitochondrial switch promotes tumor metastasis.
https://iris.unito.it/handle/2318/1657315

De Saedeleer, C J , Porporato, P E , Copetti, T , Pérez-Escuredo, J , Payen, V L , Brisson, L , Feron, O , Sonveaux, P (2014)
Glucose deprivation increases monocarboxylate transporter 1 (MCT1) expression and MCT1-dependent tumor cell migration.
https://iris.unito.it/handle/2318/1657316

Steinstraesser, Lars, Lam, Martin C, Jacobsen, Frank, Porporato, Paolo E, Chereddy, Kiran Kumar, Becerikli, Mustafa, Stricker, Ingo, Hancock, Robert EW, Lehnhardt, Marcus, Sonveaux, Pierre, Préat, Véronique*, Vandermeulen, Gaëlle (2014)
Skin electroporation of a plasmid encoding hCAP-18/LL-37 host defense peptide promotes wound healing.
https://iris.unito.it/handle/2318/1681346

Porporato P, Filigheddu N, Reano S, Ferrara M, Angelino E, Gnocchi V, Prodam F, Ronchi G, Fagoonee S, Fornaro M, Chianale F, Baldanzi G, Surico N, Sinigaglia F, Perroteau I, Smith R, Sun Y, Geuna S, Graziani A (2013)
Acylated and unacylated ghrelin impair skeletal muscle atrophy in mice.
https://iris.unito.it/handle/2318/132179

Porporato, Paolo E , Payen, Valéry L , De Saedeleer, Christophe J , Prã©at, Vã©ronique, Thissen, Jean-Paul, Feron, Olivier, Sonveaux, Pierre (2012)
Lactate stimulates angiogenesis and accelerates the healing of superficial and ischemic wounds in mice.
https://iris.unito.it/handle/2318/1658090

Federica Chianale, Elena Rainero, Cristina Cianflonea, Valentina Bettio, Andrea Pighini, Paolo Porporato, Nicoletta Filigheddu, Guido Serini, Fabiola Sinigaglia, Gianluca Baldanzi, Andrea Graziani (2010)
Diacylglycerol kinase α mediates HGF-induced Rac activation and membrane ruffling by regulating atypical PKC and RhoGDI.
https://iris.unito.it/handle/2318/76313

Audisio C, Raimondo S, Nicolino S, Gambarotta G, Di Scipio F, Macrì L, Montarolo F, Giacobini-Robecchi MG, Porporato P, Filigheddu N, Graziani A, Geuna S, Perroteau I (2009)
Morphological and biomolecular characterization of the neonatal olfactory bulb ensheathing cell line.
https://iris.unito.it/handle/2318/131011

Geuna S, Raimondo S, Ronchi G, Audisio C, Perroteau I, Porporato P, Filigheddu N, Graziani A (2009)
Increase in circulating des-acyl ghrelin promotes posttraumatic neural regeneration in the mouse peripheral nervous system.
https://iris.unito.it/handle/2318/70642

Rainero E , Chianale F , Porporato P , Cianflone C , Bettio V , Filigheddu N , Serini G , Graziani A (2009)
HGF induces cell migration, ruffling and Rac activation through a novel signalling pathway coupling diacylglycerol kinase alpha to PKCz/i and RhoGDI.
https://iris.unito.it/handle/2318/95638

BALDANZI G, CUTRUPI S, CHIANALE F, GNOCCHI V, RAINERO E, PORPORATO P, FILIGHEDDU N, VAN BLITTERSWIJK WJ, PAROLINI O, BUSSOLINO F, SINIGAGLIA F, GRAZIANI A (2008)
Diacylglycerol kinase-alpha phosphorylation by Src on Y335 is required for activation, membrane recruitment and Hgf-induced cell motility.
https://iris.unito.it/handle/2318/35817

FILIGHEDDU N, CUTRUPI S, PORPORATO PE, RIBONI F, BALDANZI G, CHIANALE F, FORTINA E, PIANTANIDA P, M DE BORTOLI, VACCA G, GRAZIANI A, SURICO N (2007)
Diacylglycerol Kinase is Required for HGF-induced Invasiveness and Anchorage-independent Growth of MDA-MB-231 Breast Cancer Cells.
https://iris.unito.it/handle/2318/4341

CHIANALE F, S CUTRUPI, RAINERO E, BALDANZI G, PORPORATO PE, TRAINI S, FILIGHEDDU N, GNOCCHI VF, SANTORO MM, PAROLINI O, VAN BLITTERSWIJK WJ, SINIGAGLIA, F, GRAZIANI A (2007)
Diacylglycerol Kinase-{alpha} Mediates HGF-induced Epithelial Cell Scatter by Regulating Rac Activation and Membrane Ruffling.
https://iris.unito.it/handle/2318/21544

FILIGHEDDU N, GNOCCHI VF, COSCIA M, CAPPELLI M, PORPORATO PE, TAULLI R, TRAINI S, BALDANZI G, CHIANALE F, CUTRUPI S, ARNOLETTI E, GHE C, FUBINI A, SURICO N, SINIGAGLIA F, PONZETTO C, MUCCIOLI G, CREPALDI T, GRAZIANI A (2007)
Ghrelin and Des-Acyl Ghrelin Promote Differentiation and Fusion of C2c12 Skeletal Muscle Cells.
https://iris.unito.it/handle/2318/39617

A GRAZIANI, V GNOCCHI, N FILIGHEDDU, M COSCIA, L BADA, F SOTTINI, S TRAINI, P PORPORATO, F CHIANALE, G BRIGNOLI, G BALDANZI, R TAULLI, T CREPALDI, F SINIGAGLIA (2006)
Ghrelin induces differentiation and fusion of C2C12 myoblasts and protects myotubes from atrophy.
https://iris.unito.it/handle/2318/70015

Bondi A, Valentino P, Daraio F, Porporato P, Gramaglia E, Carturan S, Gottardi E, Camaschella C, Roetto A (2005)
Hepatic expression of hemochromatosis genes in two mouse strains after phlebotomy and iron overload.
https://iris.unito.it/handle/2318/147939

Roetto A, Daraio F, Porporato P, Caruso R, Cox TM, Cazzola M, Gasparini P, Piperno A, Camaschella C (2004)
Screening hepcidin for mutations in juvenile hemochromatosis: identification of a new mutation (C70R).
https://iris.unito.it/handle/2318/147857

C Camaschella, S Bosio, M De Gobbi, G Zecchina, F Daraio, P Porporato, F Longo, A Piga, A Roetto (2003)
Rare Genetic Anemias Due to Defective Iron Recycling: Aceruloplasminemia and Type 4 Hemochromatosis.
https://iris.unito.it/handle/2318/123109

A Roetto, F Daraio, F Alberti, P Porporato, A Calì, M De Gobbi, C Camaschella (2002)
Hemochromatosis due to mutations in transferrin receptor 2.
https://iris.unito.it/handle/2318/90159

Courses

• ADE Basi biologiche e molecolari di patologie tumorali e cardiovascolari (SME1062)
  Laurea Magistrale in Medicina e Chirurgia - sede di Torino
• BASIS OF BIOSAFETY AND BIOSECURITY (ON LINE) (CPS0997 - MAN0706)
  Scuola Universitaria Interdipartimentale in Scienze Strategiche (SUISS)
• Basi biologiche (canale C) (SME0881A)
  Laurea Magistrale in Medicina e Chirurgia - sede di Torino
• Basi biologiche (canale D) (SME0881A)
  Laurea Magistrale in Medicina e Chirurgia - sede di Torino
• Basi biologiche, molecolari e di genetica umana (canale C) (SME0881)
  Laurea Magistrale in Medicina e Chirurgia - sede di Torino
• Basi biologiche, molecolari e di genetica umana (canale D) (SME0881)
  Laurea Magistrale in Medicina e Chirurgia - sede di Torino
• Cellular Biology (Sezione 1) (BIO0174C)
  Corso di Laurea in Biotecnologie
• Cellular Biology (Sezione 2) (BIO0174C)
  Corso di Laurea in Biotecnologie
• ELEMENTI DI BIOSICUREZZA (CPS0723)
  Scuola Universitaria Interdipartimentale in Scienze Strategiche (SUISS)
• INTEGRATED LABORATORY TECNIQUES (BIO0174)
  Corso di Laurea in Biotecnologie
• IN VITRO DIAGNOSTICS: PROTEOMICS, INTERACTOMICS AND METABOLOMICS (BIO0162 Pds 308-BIDD)
  Master Program in Molecular Biotechnology

Research topics

Gruppi di ricerca

Cancer Metabolism And Cachexia

Activities in agenda

See my calendar

Academic bodies

• Commissione Terza Missione 2024_2027
• Consiglio di Dipartimento
• Giunta di Dipartimento 2024_2027
• MBC_ Composizione Comitato Scientifico

• Monitoring and Reassessment Committee

Office hours