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Di Savino, A., Panuzzo, C., Rocca, S., Familiari, U., Piazza, R., Crivellaro, S., Carra, G., Ferretti, R., Fusella, F., Giugliano, E., Camporeale, A., Franco, I., Miniscalco, B., Cutrin, J.C., Turco, E., Silengo, L., Hirsch, E., Rege-Cambrin, G., Gambacorti-Passerini, C., Pandolfi, P.P., Papotti, M., Saglio, G., Tarone, G., Morotti, A. and Brancaccio, M. Morgana acts as an oncosuppressor in chronic myeloid leukemia. Blood (2015).

Tarone, G. and Brancaccio, M. The muscle-specific chaperone protein melusin is a potent cardioprotective agent. Basic Res Cardiol110, 10 (2015).

Unsold, B., Kaul, A., Sbroggio, M., Schubert, C., Regitz-Zagrosek, V., Brancaccio, M., Damilano, F., Hirsch, E., Van Bilsen, M., Munts, C., Sipido, K., Bito, V., Detre, E., Wagner, N.M., Schafer, K., Seidler, T., Vogt, J., Neef, S., Bleckmann, A., Maier, L.S., Balligand, J.L., Bouzin, C., Ventura-Clapier, R., Garnier, A., Eschenhagen, T., El-Armouche, A., Knoll, R., Tarone, G. and Hasenfuss, G. Melusin protects from cardiac rupture and improves functional remodelling after myocardial infarction. Cardiovasc Res 101, 97-107 (2014).

Tarone, G. and Brancaccio, M. Keep your heart in shape: molecular chaperone networks for treating heart disease. Cardiovasc Res 102, 346-61 (2014).

Penna, C., Brancaccio, M., Tullio, F., Rubinetto, C., Perrelli, M.G., Angotti, C., Pagliaro, P. and Tarone, G. Overexpression of the muscle-specific protein, melusin, protects from cardiac ischemia/reperfusion injury. Basic Res Cardiol 109, 418 (2014).

Fusella, F., Ferretti, R., Recupero, D., Rocca, S., Di Savino, A., Tornillo, G., Silengo, L., Turco, E., Cabodi, S., Provero, P., Pandolfi, P.P., Sapino, A., Tarone, G. and Brancaccio, M. Morgana acts as a proto-oncogene through inhibition of a ROCK-PTEN pathway. J Pathol 234, 152-63 (2014).

Tarone, G., Sbroggio, M. and Brancaccio, M. Key role of ERK1/2 molecular scaffolds in heart pathology. Cell Mol Life Sci 70, 4047-54 (2013).

Waardenberg, A.J., Bernardo, B.C., Ng, D.C., Shepherd, P.R., Cemerlang, N., Sbroggio, M., Wells, C.A., Dalrymple, B.P., Brancaccio, M., Lin, R.C. and McMullen, J.R. Phosphoinositide 3-kinase (PI3K(p110alpha)) directly regulates key components of the Z-disc and cardiac structure. J Biol Chem 286, 30837-46 (2011).

Sbroggio, M., Carnevale, D., Bertero, A., Cifelli, G., De Blasio, E., Mascio, G., Hirsch, E., Bahou, W.F., Turco, E., Silengo, L., Brancaccio, M., Lembo, G. and Tarone, G. IQGAP1 regulates ERK1/2 and AKT signalling in the heart and sustains functional remodelling upon pressure overload. Cardiovasc Res 91, 456-64 (2011).

Sbroggio, M., Bertero, A., Velasco, S., Fusella, F., De Blasio, E., Bahou, W.F., Silengo, L., Turco, E., Brancaccio, M. and Tarone, G. ERK1/2 activation in heart is controlled by melusin, focal adhesion kinase and the scaffold protein IQGAP1. J Cell Sci 124, 3515-24 (2011).

Hanashiro, K., Brancaccio, M. and Fukasawa, K. Activated ROCK II by-passes the requirement of the CDK2 activity for centrosome duplication and amplification. Oncogene (2011).

Ferretti, R., Sbroggio, M., Di Savino, A., Fusella, F., Bertero, A., Michowski, W., Tarone, G. and Brancaccio, M. Morgana and melusin: two fairies chaperoning signal transduction. Cell Cycle 10, 3678-83 (2011).

Michowski, W., Ferretti, R., Wisniewska, M.B., Ambrozkiewicz, M., Beresewicz, M., Fusella, F., Skibinska-Kijek, A., Zablocka, B., Brancaccio, M., Tarone, G. and Kuznicki, J. Morgana/CHP-1 is a novel chaperone able to protect cells from stress. Biochim Biophys Acta (2010).

Ferretti, R., Palumbo, V., Di Savino, A., Velasco, S., Sbroggio, M., Sportoletti, P., Micale, L., Turco, E., Silengo, L., Palumbo, G., Hirsch, E., Teruya-Feldstein, J., Bonaccorsi, S., Pandolfi, P.P., Gatti, M., Tarone, G. and Brancaccio, M. Morgana/chp-1, a ROCK inhibitor involved in centrosome duplication and tumorigenesis. Dev Cell 18, 486-95 (2010).

Palumbo, V., Segat, L., Padovan, L., Amoroso, A., Trimarco, B., Izzo, R., Lembo, G., Regitz-Zagrosek, V., Knoll, R., Brancaccio, M., Tarone, G. and Crovella, S. Melusin gene (ITGB1BP2) nucleotide variations study in hypertensive and cardiopathic patients. BMC Med Genet 10, 140 (2009).

Brancaccio, M., Turco, E. and Hirsch, E. Tissue-specific KO of ECM proteins. Methods Mol Biol 522, 15-50 (2009).

Sbroggio, M., Ferretti, R., Percivalle, E., Gutkowska, M., Zylicz, A., Michowski, W., Kuznicki, J., Accornero, F., Pacchioni, B., Lanfranchi, G., Hamm, J., Turco, E., Silengo, L., Tarone, G. and Brancaccio, M. The mammalian CHORD-containing protein melusin is a stress response protein interacting with Hsp90 and Sgt1. FEBS Lett 582, 1788-94 (2008).

Volpe, G., Cignetti, A., Panuzzo, C., Kuka, M., Vitaggio, K., Brancaccio, M., Perrone, G., Rinaldi, M., Prato, G., Fava, M., Geuna, M., Pautasso, M., Casnici, C., Signori, E., Tonon, G., Tarone, G., Marelli, O., Fazio, V.M. and Saglio, G. Alternative BCR/ABL splice variants in Philadelphia chromosome-positive leukemias result in novel tumor-specific fusion proteins that may represent potential targets for immunotherapy approaches. Cancer Res 67, 5300-7 (2007).

Brokat, S., Thomas, J., Herda, L.R., Knosalla, C., Pregla, R., Brancaccio, M., Accornero, F., Tarone, G., Hetzer, R. and Regitz-Zagrosek, V. Altered melusin expression in the hearts of aortic stenosis patients. Eur J Heart Fail 9, 568-73 (2007).

Brancaccio, M., Hirsch, E., Notte, A., Selvetella, G., Lembo, G. and Tarone, G. Integrin signalling: the tug-of-war in heart hypertrophy. Cardiovasc Res 70, 422-33 (2006).

Vecchione, C., Patrucco, E., Marino, G., Barberis, L., Poulet, R., Aretini, A., Maffei, A., Gentile, M.T., Storto, M., Azzolino, O., Brancaccio, M., Colussi, G.L., Bettarini, U., Altruda, F., Silengo, L., Tarone, G., Wymann, M.P., Hirsch, E. and Lembo, G. Protection from angiotensin II-mediated vasculotoxic and hypertensive response in mice lacking PI3Kgamma. J Exp Med 201, 1217-28 (2005).

De Acetis, M., Notte, A., Accornero, F., Selvetella, G., Brancaccio, M., Vecchione, C., Sbroggio, M., Collino, F., Pacchioni, B., Lanfranchi, G., Aretini, A., Ferretti, R., Maffei, A., Altruda, F., Silengo, L., Tarone, G. and Lembo, G. Cardiac overexpression of melusin protects from dilated cardiomyopathy due to long-standing pressure overload. Circ Res 96, 1087-94 (2005).ìPatrucco, E., Notte, A., Barberis, L., Selvetella, G., Maffei, A., Brancaccio, M., Marengo, S., Russo, G., Azzolino, O., Rybalkin, S.D., Silengo, L., Altruda, F., Wetzker, R., Wymann, M.P., Lembo, G. and Hirsch, E. PI3Kgamma modulates the cardiac response to chronic pressure overload by distinct kinase-dependent and -independent effects. Cell 118, 375-87 (2004).​

Brancaccio, M., Fratta, L., Notte, A., Hirsch, E., Poulet, R., Guazzone, S., De Acetis, M., Vecchione, C., Marino, G., Altruda, F., Silengo, L., Tarone, G. and Lembo, G. Melusin, a muscle-specific integrin beta1-interacting protein, is required to prevent cardiac failure in response to chronic pressure overload. Nat Med 9, 68-75 (2003).

Anastasi, G., Amato, A., Tarone, G., Vita, G., Monici, M.C., Magaudda, L., Brancaccio, M., Sidoti, A., Trimarchi, F., Favaloro, A. and Cutroneo, G. Distribution and localization of vinculin-talin-integrin system and dystrophin-glycoprotein complex in human skeletal muscle. Immunohistochemical study using confocal laser scanning microscopy. Cells Tissues Organs 175, 151-64 (2003).

Hirsch, E., Barberis, L., Brancaccio, M., Azzolino, O., Xu, D., Kyriakis, J.M., Silengo, L., Giancotti, F.G., Tarone, G., Fassler, R. and Altruda, F. Defective Rac-mediated proliferation and survival after targeted mutation of the beta1 integrin cytodomain. J Cell Biol 157, 481-92 (2002)

Degani, S., Balzac, F., Brancaccio, M., Guazzone, S., Retta, S.F., Silengo, L., Eva, A. and Tarone, G. The integrin cytoplasmic domain-associated protein ICAP-1 binds and regulates Rho family GTPases during cell spreading. J Cell Biol 156, 377-87 (2002).

Tarone, G., Hirsch, E., Brancaccio, M., De Acetis, M., Barberis, L., Balzac, F., Retta, S.F., Botta, C., Altruda, F. and Silengo, L. Integrin function and regulation in development. Int J Dev Biol 44, 725-31 (2000).

Hirsch, E., Brancaccio, M. and Altruda, F. Tissue-specific KO of ECM proteins. Methods Mol Biol 139, 147-78 (2000).

Barberis, L., Wary, K.K., Fiucci, G., Liu, F., Hirsch, E., Brancaccio, M., Altruda, F., Tarone, G. and Giancotti, F.G. Distinct roles of the adaptor protein Shc and focal adhesion kinase in integrin signaling to ERK. J Biol Chem 275, 36532-40 (2000).

Brancaccio, M., Guazzone, S., Menini, N., Sibona, E., Hirsch, E., De Andrea, M., Rocchi, M., Altruda, F., Tarone, G. and Silengo, L. Melusin is a new muscle-specific interactor for b1 integrin cytoplasmic domain. J Biol Chem 274, 29282-8 (1999).

Brancaccio, M., Cabodi, S., Belkin, A.M., Collo, G., Koteliansky, V.E., Tomatis, D., Altruda, F., Silengo, L. and Tarone, G. Differential onset of expression of alpha 7 and beta 1D integrins during mouse heart and skeletal muscle development. Cell Adhes Commun5, 193-205 (1998). 

Last update: 21/09/2018 23:32
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