Department of Molecular Biotechnology and Health Sciences

Selected research products

1. Desole C, Gallo S, Vitacolonna A, Montarolo F, Bertolotto A, Vivien D, Comoglio P, Crepaldi T. HGF and MET: From brain development to neurological disorders. Front Cell and Developmental Biology 09 June 2021. doi.org/10.3389/fcell.2021.683609. PMID: 34179015
2. Balbo I, Montarolo F, Boda E, Tempia F, Hoxha E. Elovl5 Expression in the Central Nervous System of the Adult Mouse. Front Neuroanat. 2021 Apr 29;15:669073. doi: 10.3389/fnana.2021.669073. PMID: 33994961
3. Montarolo F*, Martire S*, Spadaro M, Perga S, Sforza ML, Marozio L, Frezet F, Bruno S, Chiabotto G, Deregibus MC, Camussi G, Botta G, Benedetto C, Bertolotto A. A First Phenotypic and Functional Characterization of Placental Extracellular Vesicles from Women with Multiple Sclerosis. Int J Mol Sci. 2021 Mar 12;22(6):2875. doi: 10.3390/ijms22062875. PMCID: PMC8001892
4. Parolisi R, Montarolo F, Pini A, Rovelli S, Cattaneo A, Bertolotto A, Buffo A, Bollati V, Boda E. Exposure to fine particulate matter (PM2.5) hampers myelin repair in a mouse model of white matter demyelination. Neurochem Int. 2021 Feb 12:104991. doi: 10.1016/j.neuint.2021.104991. Online ahead of print. PMID: 33587955
5. Perga S, Montarolo F, Martire S, Bonaldo B, Bono G, Bertolo J, Magliozzi R, Bertolotto A. Overexpression of the ubiquitin-editing enzyme A20 in the brain lesions of Multiple Sclerosis patients: moving from systemic to central nervous system inflammation. Brain Pathol. 2020 Oct 14: e12906. doi: 10.1111/bpa.12906. Online ahead of print. PMID: 33051914
6. Montarolo F, Perga S, Tessarolo C, Spadaro M, Martire S, Bertolotto A. TNFAIP3 Deficiency Affects Monocytes, Monocytes-Derived Cells and Microglia in Mice. Int J Mol Sci. 2020 Apr 18;21(8):2830. doi: 10.3390/ijms21082830.PMID: 32325694
7. Valsecchi V, Boido M, Montarolo F, Guglielmotto M, Perga S, Martire S, Cutrupi S, Iannello A, Gionchiglia N, Signorino E, Calvo A, Fuda G, Chiò A, Bertolotto A, Vercelli A. The transcription factor Nurr1 is upregulated in amyotrophic lateral sclerosis patients and SOD1-G93A mice. Dis Model Mech. 2020 May 15;13(5): dmm043513. doi: 10.1242/dmm.043513. PMID: 32188741
8. Marangon D, Boda E, Parolisi R, Negri C, Giorgi C, Montarolo F, Perga S, Bertolotto A, Buffo A, Abbracchio MP, Lecca D. In vivo silencing of miR-125a-3p promotes myelin repair in models of white matter demyelination. Glia. 2020 Mar 12. doi: 10.1002/glia.23819. Online ahead of print. PMID: 32163190
9. Montarolo F, Martire S, Perga S and Bertolotto A. NURR1 Impairment in Multiple Sclerosis. Int. J. Mol. Sci. 2019, 20, 4858; doi:10.3390/ijms20194858. PMID: 31574937
10. Montarolo F, Martire S, Perga S, Spadaro M, Brescia I, Allegra S, De Francia S and Bertolotto A. NURR1 deficiency is associated to ADHD-like phenotypes in mice. TranslationalPsychiatry. 2019, 9:207. doi: 10.1038/s41398-019-0544-0. PMID: 31455763
11. Spadaro M, Martire S, Marozio L, Mastromauro D, Montanari E, Perga S, Montarolo F, Brescia F, Balbo A, Botta G, Benedetto C and Bertolotto A. Immunomodulatory Effect of Pregnancy on Leukocyte Populations in Patients with Multiple Sclerosis: A Comparison of Peripheral Blood and Decidual Placental Tissue. Front. Immunol. 2019, 10:1935. doi: 10.3389/fimmu.2019.01935. PMID: 31474999
12. Montarolo F, Perga S, Martire S, Brescia F, Caldano M, Lo Re M, Panzica G, Bertolotto A. Study of the NR4A family gene expression in patients with multiple sclerosis treated with Fingolimod. Eur J Neurol. 2019 Apr;26(4):667-672. doi: 10.1111/ene.13875. PMID: 30565812
13. Mancini C, Hoxha E, Iommarini L, Brussino A, Richter U, Montarolo F, Cagnoli C, Parolisi R, GondorMorosini DI, Nicolò V, Maltecca F, Muratori L, Ronchi G, Geuna S, Arnaboldi F, Donetti E, Giorgio E, Cavalieri S, Di Gregorio E, Pozzi E, Ferrero M, Riberi E, Casari G, Altruda F, Turco E, Gasparre G, Battersby BJ, Porcelli AM, Ferrero E, Brusco A, Tempia F. Mice harbouring a SCA28 patientmutation in AFG3L2 develop late-onsetataxiaassociated with enhancedmitochondrialproteotoxicity. Neurobiol Dis. 2019 Apr; 124:14-28. doi: 10.1016/j.nbd.2018.10.018. Epub 2018 Oct 30. PMID: 30389403
14. Hoxha E, Marcinnò A, Montarolo F, Masante L, Balbo I, Ravera F, Laezza F, Tempia F. Emergingroles of Fgf14 in behavioral control. Behav Brain Res. 2019 Jan 1; 356:257-265. doi: 10.1016/j.bbr.2018.08.034. Epub 2018 Sep 3. PMID: 30189289
15. Perga S, Martire S, Montarolo F, Giordani I, Spadaro M, Bono G, Corvisieri S, Messuti I, Panzica G, Orlandi F, Bertolotto A. The Footprints of Poly-Autoimmunity: Evidence for Common Biological Factors Involved in Multiple Sclerosis and Hashimoto's Thyroiditis. Front Immunol. 2018 Feb 20; 9:311. doi: 10.3389/fimmu.2018.00311. eCollection 2018. PMID: 29527211
16. Spadaro M, Montarolo F, Perga S, Martire S, Brescia F, Malucchi S, Bertolotto A. Biological activity of glatiramer acetate on Treg and anti-inflammatory monocytes persists for more than 10 years in responder multiple sclerosis patients. Clinimmunol. 2017 Jul 1; 181:83–88. doi: 10.1016/j.clim.2017.06.006. Epub 2017 Jun 19. PMID: 28642148
17. Perga S, Martire S, Montarolo F, Navone ND, Calvo A, Fuda G, Marchet A, Leotta D, Chiò A, Bertolotto A. A20 in Multiple Sclerosis and Parkinson's Disease: Clue to a Common Dysregulation of Anti-Inflammatory Pathways? Neurotox Res. 2017 Jul;32(1):1-7. doi: 10.1007/s12640-017-9724-y. Epub 2017 Mar 23. PMID: 28337659
18. Pellegrino RM, Boda E, Montarolo F, Boero M, Mezzanotte M, Saglio G, Buffo A, Roetto A. Transferrin Receptor 2 Dependent Alterations of Brain Iron Metabolism Affect Anxiety Circuits in the Mouse. Scientific Rep. 2016 Aug 1; 6:30725. doi: 10.1038/srep30725. PMID: 27477597
19. Montarolo F, Martire S, Perga S, Navone ND, Marchet A, Leotta D, Bertolotto A. Altered NR4A subfamily gene expression level in peripheral blood of Parkinson's and Alzheimer's disease patients. Neurotox Res. 2016 May 9; doi. 0.1007/s12640-016-9626-4. PMID: 27159982
20. Martire S, Navone ND, Montarolo F, Perga S, Bertolotto A. A gene expression study denies the ability of 25 candidate biomarkers to predict the interferon-beta treatment response in multiple sclerosis patients. J Neuroimmunol. 2016 Mar 15; 292:34-9. doi: 10.1016/j.jneuroim.2016.01.010. Epub 2016 Jan 16. PMID: 26943956
21. Montarolo F, Perga S, Martire S, Bertolotto A. Nurr1 reduction influences the onset of chronic EAE in mice. Inflamm Res. 2015 Nov;64(11):841-4. doi: 10.1007/s00011-015-0871-4. Epub 2015 Sep 4. PMID: 26337347
22. Perga S, Montarolo F, Martire S, Berchialla P, Malucchi S, Bertolotto A. Anti-inflammatory genes associated with multiple sclerosis: a gene expression study. J Neuroimmunol. 2015 Feb 15; 279:75-8. doi: 10.1016/j.jneuroim.2015.01.004. Epub 2015 Jan 21. PMID: 25670004
23. Montarolo F, Raffaele C, Perga S, Martire S, Finardi A, Furlan R, Hintermann S, Bertolotto A. Effects of isoxazolo-pyridinone 7e, a potent activator of the Nurr1 signaling pathway, on experimental autoimmune encephalomyelitis in mice. PLoSOne. 2014 Sep 29;9(9):e108791. doi: 10.1371/journal.pone.0108791. eCollection 2014. PMID: 25265488
24. Di Gregorio E, Bianchi FT, Schiavi A, Chiotto AM, Rolando M, Verdun di Cantogno L, Grosso E, Cavalieri S, Calcia A, Lacerenza D, Zuffardi O, Retta SF, Stevanin G, Marelli C, Durr A, Forlani S, Chelly J, Montarolo F, Tempia F, Beggs HE, Reed R, Squadrone S, Abete MC, Brussino A, Ventura N, Di Cunto F, Brusco A. A de novo X;8 translocationcreates a PTK2-THOC2 gene fusion with THOC2 expression knockdown in a patient with psychomotorretardation and congenitalcerebellarhypoplasia. J Med Genet. 2013 Aug;50(8):543-51. doi: 10.1136/jmedgenet-2013-101542. Epub 2013 Jun 7. PMID: 23749989
25. Montarolo F, Parolisi R, Hoxha E, Boda E, Tempia F. Early enriched environment exposure protects spatial memory and accelerates amyloid plaque formation in APP(Swe)/PS1(L166P) mice. PLoSOne. 2013 Jul 24;8(7):e69381. doi: 10.1371/journal.pone.0069381. Print 2013. PMID: 23894463
26. Hoxha E, Tonini R, Montarolo F, Croci L, Consalez GG, Tempia F. Motor dysfunction and cerebellar Purkinje cell firing impairment in Ebf2 null mice. Mol Cell Neurosci. 2013 Jan; 52:51-61. doi: 10.1016/j.mcn.2012.09.002. Epub 2012 Sep 18. PMID: 23000673
27. Hoxha E, Boda E, Montarolo F, Parolisi R, Tempia F. Excitability and synaptic alterations in the cerebellum of APP/PS1 mice. PLoS One. 2012;7(4):e34726. doi: 10.1371/journal.pone.0034726. Epub 2012 Apr 12. PMID: 22511962
28. Boda E, Hoxha E, Pini A, Montarolo F, Tempia F. Brain expression of Kv3 subunits during development, adulthood and aging and in a murine model of Alzheimer's disease. J MolNeurosci. 2012 Mar;46(3):606-15. doi: 10.1007/s12031-011-9648-6. Epub 2011 Sep 13. PMID: 21912965
29. Audisio C, Raimondo S, Nicolino S, Gambarotta G, Di Scipio F, Macrì L, Montarolo F, Giacobini-Robecchi MG, Porporato P, Filigheddu N, Graziani A, Geuna S, Perroteau I. Morphological and biomolecular characterization of the neonatal olfactory bulb ensheathing cell line. J Neurosci Methods. 2009 Dec 15;185(1):89-98. doi: 10.1016/j.jneumeth.2009.09.021. Epub 2009 Sep 26. PMID: 19786050

Courses

• Fisiologia (SUI0160_CN)
  Corso di laurea Scienze delle Attività Motorie e Sportive L-22 - Cuneo

Research groups

• Neurofisiologia delle malattie neurodegenerative

Activities in agenda

See my calendar

Academic bodies

• Comunicazione docenti a.a. 2022/23
• Consiglio di Corso di Laurea in Scienze delle Attività Motorie e Sportive L-22

Office hours