Department of Molecular Biotechnology and Health Sciences

Research products

Selected research products

Anemone A, Consolino L, Arena F, Capozza M, Longo DL. (2019) Imaging tumor acidosis: a survey of the available techniques for mapping in vivo tumor pH. Cancer metastasis reviews 38(1-2) 25-49 [DOI  PMID]

Consolino L, Longo DL, Sciortino M, Dastru W, Cabodi S, Giovenzana GB, Aime S. (2017) Assessing tumor vascularization as a potential biomarker of imatinib resistance in gastrointestinal stromal tumors by dynamic contrast-enhanced magnetic resonance imaging. Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association 20(4) 629-639 [DOI  PMID]

Longo DL, Bartoli A, Consolino L, Bardini P, Arena F, Schwaiger M, Aime S. (2016) In Vivo Imaging of Tumor Metabolism and Acidosis by Combining PET and MRI-CEST pH Imaging. Cancer research 76(22) 6463-6470 [DOI  PMID]

Consolino L, Longo DL, Dastru W, Cutrin JC, Dettori D, Lanzardo S, Oliviero S, Cavallo F, Aime S. (2016) Functional imaging of the angiogenic switch in a transgenic mouse model of human breast cancer by dynamic contrast enhanced magnetic resonance imaging. International journal of cancer 139(2) 404-13 [DOI  PMID]

Longo DL, Arena F, Consolino L, Minazzi P, Geninatti-Crich S, Giovenzana GB, Aime S. (2016) Gd-AAZTA-MADEC, an improved blood pool agent for DCE-MRI studies on mice on 1 T scanners. Biomaterials 75 47-57 [DOI  PMID]

Longo DL, Dastru W, Consolino L, Espak M, Arigoni M, Cavallo F, Aime S. (2015) Cluster analysis of quantitative parametric maps from DCE-MRI: application in evaluating heterogeneity of tumor response to antiangiogenic treatment. Magnetic resonance imaging 33(6) 725-36 [DOI  PMID]

Longo DL, Di Gregorio E, Abategiovanni R, Ceccon A, Assfalg M, Molinari H, Aime S. (2014) Chemical exchange saturation transfer (CEST): an efficient tool for detecting molecular information on proteins' behaviour. The Analyst 139(11) 2687-90 [DOI  PMID]

Longo DL, Busato A, Lanzardo S, Antico F, Aime S. (2013) Imaging the pH evolution of an acute kidney injury model by means of iopamidol, a MRI-CEST pH-responsive contrast agent. Magnetic resonance in medicine 70(3) 859-64 [DOI  PMID]

Courses

• IN VIVO IMAGING OF CANCER THERAPY (BIO0188 Pds GEN)
  Master Program in Molecular Biotechnology

Research topics

Dario Longo lab aims to develop novel magnetic resonance imaging (MRI)-based methods for characterizing tumor microenvironment properties (acidosis, vascularization, hypoxia) in murine tumor models. We are interested in developing and validating non-invasive MRI procedures and probes for improving diagnosis and assessment of treatment effects with a special focus on tumor metabolism and on antiangiogenic drugs.

Our current projects include:

• Imaging tumor acidosis and angiogenesis
• assessing pH imaging as a novel biomarker in cancer and in renal diseases
• development of novel MRI-based probes for assessing tumor microenvironment

More information about research activities can be found at:

Longo Lab

Gruppi di ricerca

Imaging Tumor Microenvironment 

Research groups

• Imaging Molecolare

Activities in agenda

See my calendar

Academic bodies

• MBC_ Composizione Comitato di Gestione
• MBC_ Composizione Comitato Scientifico